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Southern Chicken Spaghetti Casserole

Southern Chicken Spaghetti Casserole

This Southern Chicken Spaghetti Casserole is the ultimate comfort food! Creamy, cheesy, and loaded with tender chicken and perfectly cooked spaghetti, this easy casserole brings the flavors of the South straight to your dinner table. Perfect for busy weeknights, potlucks, or cozy family dinners, this baked chicken spaghetti is one of the best easy casserole recipes you’ll ever make.
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Prep Time 15 minutes
Cook Time 30 minutes
Total Time 45 minutes
Servings: 6
Ingredients Method Notes

Ingredients
  

  • 2 cups cooked shredded chicken rotisserie or boiled
  • 8 oz spaghetti cooked and drained
  • 1 can 10.5 oz cream of mushroom soup (or cream of chicken soup)
  • 1 can 10 oz Rotel tomatoes with green chilies
  • 1 cup sour cream
  • 1 small onion finely chopped
  • 2 cups shredded cheddar cheese divided
  • 1 tsp garlic powder
  • 1 tsp onion powder
  • Salt and black pepper to taste
  • 1 tbsp butter or olive oil for sautéing
  • Optional: Crushed crackers breadcrumbs, or Parmesan for topping

Method
 

  1. Cook spaghetti according to package instructions. Drain and set aside.
  2. In a skillet, sauté onion in butter or olive oil until soft and fragrant.
  3. In a large bowl, combine cooked chicken, soup, Rotel, sour cream, garlic powder, onion powder, salt, and pepper. Stir until smooth and creamy.
  4. Add cooked spaghetti and half of the cheese. Mix until the pasta is evenly coated.
  5. Transfer mixture into a greased casserole dish. Sprinkle the remaining cheese on top.
  6. Bake at 350°F (175°C) for 25–30 minutes, or until bubbly and golden brown.
  7. Serve warm, garnished with fresh parsley or green onions if desired.

Notes

  • For extra creaminess, stir in 4 oz cream cheese or ½ cup heavy cream before baking.
  • Add mushrooms, peas, or spinach for extra veggies.
  • Make ahead: Assemble the casserole, cover, and refrigerate for up to 24 hours before baking.